RAF Typhoon FGR4s have operated alongside France's air force in a combined operation targeting an subterranean weapons facility in Syrian territory employed by the IS group, as stated by the British defence ministry.
The location, located using intelligence, was assessed as containing munitions and bombs, the announcement noted, and was situated in hills just above the ancient city of Palmyra in central Syria.
"Our fighter planes utilized Paveway IV guided bombs to strike a several access tunnels providing entry to the site... initial indications indicate the target was engaged successfully," the ministry announced.
There was no sign of any civilian casualties in the attack conducted Saturday night and each participating jet returned safely, the MoD added.
The Typhoon fighters were supported by a Voyager aerial refuelling aircraft.
Daesh - referred to as ISIS - imposed militant control over parts of both Syria and Iraq before its territorial defeat in 2019.
"This action shows the UK's leading role, and commitment to operate in unison with our partners, to stamp out any revival of Daesh and their harmful and extremist ideologies in the region," Britain's Defence Chief the Defence Secretary remarked.
British military aircraft have conducted surveillance missions over Syria to "deter any attempted resurgence" of IS subsequent to its routing at the climactic battle in Baghuz in 2019, the authorities noted.
"I want to thank all the members of our armed forces who took part in this operation for their expertise and their courage," Healey said. "They were part of a great many British troops on duty over Christmas and New Year. This mission, to remove dangerous terrorists who threaten our security, demonstrates how UK forces are prepared to act, continuously, protecting the UK within its borders and influential overseas."
In December, the United States armed forces executed what it described as a "major assault" on Daesh sites in Syria, subsequent to an ambush claimed the lives of two US troops and a civilian linguist in the Palmyra area.
The U.N. says Islamic State still has between 5,000 and 7,000 combatants in Iraq and Syria.